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Factors influencing medication adherence after epilepsy surgery
Jianming Liu1, Ruxiang Xu1, Zhiliang Liu1
1Affiliated Bayi Brain Hospital, Bayi Clinical College, Southern Medical University, Beijing, China.
Epilepsy surgery improves antiepileptic drug (AED) adherence, yet non-compliance remains a significant postsurgical issue. Targeted management and communication strategies are crucial for enhancing medication adherence in epilepsy patients.
Area of Science:
- Neurology
- Pharmacology
- Clinical Medicine
Background:
- Treatment non-compliance is a primary driver of seizure recurrence in epilepsy patients.
- Adherence to antiepileptic drugs (AEDs) post-epilepsy surgery has not been extensively studied.
Purpose of the Study:
- To assess adherence to prescribed AEDs in patients following epilepsy surgery.
- To identify factors contributing to treatment non-compliance in this population.
Main Methods:
- A cohort of 214 postsurgical epilepsy patients was monitored for an average of 18.1 months.
- Medication Possession Ratio (MPR) and self-report questionnaires were used to measure adherence, with MPR < 0.8 indicating non-adherence.
Main Results:
- Over 27% of patients (58/214) exhibited non-adherence post-surgery.
- Non-adherence was not correlated with demographic factors, clinical variables, or surgical outcomes (Engel classification).
- Key reasons for non-adherence included extended seizure-free periods, forgetfulness, and medication accessibility issues.
Conclusions:
- While epilepsy surgery appears to enhance AED adherence compared to presurgical levels, it remains a prevalent challenge.
- Developing targeted postsurgical management programs and effective communication strategies is essential to improve AED adherence after epilepsy surgery.
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