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Published on: December 2, 2016
Multi-drug-resistant hypertension caused by severe aortic coarctation presenting in late adulthood
Stephanie M Meller1, John T Fahey, John F Setaro
1Division of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Insights
Aortic coarctation can cause difficult-to-treat hypertension in adults. Stent implantation effectively managed a patient's refractory hypertension, suggesting this treatment for adult coarctation.
Area of Science:
- Cardiology
- Vascular Surgery
- Hypertension Research
Background:
- Aortic coarctation is a rare congenital defect causing adult hypertension.
- Refractory hypertension requires thorough etiological investigation.
Observation:
- A female patient in her late 50s presented with severe, multi-drug-resistant hypertension.
- Elevated renin levels and imaging confirmed aortic coarctation.
Findings:
- Percutaneous stent implantation successfully treated the aortic coarctation.
- The patient achieved blood pressure control with single-drug therapy (verapamil).
Implications:
- Endovascular stent implantation is an effective treatment for adult aortic coarctation.
- Clinicians should consider aortic coarctation in adult refractory hypertension differential diagnoses.
- This approach may improve long-term outcomes for patients with coarctation-induced hypertension.
Abstract:
Aortic coarctation, a congenital narrowing in the region of the ligamentum arteriosium, is a rare etiology for multi-drug-resistant hypertension in adulthood; however, advances in stenting modalities may offer long-term improvements in morbidity and possibly even cure. We report on a female patient in her late 50s presenting with refractory hypertension and severely elevated renin levels, ultimately diagnosed with aortic coarctation and treated with percutaneous stent implantation, which resulted in successful blood pressure control with verapamil monotherapy. This case highlights the efficacy of endovascular stent implantation for the treatment of coarctation and the need for clinicians to consider this disease entity in the differential diagnosis of refractory hypertension even in late adulthood.
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