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Related Experiment Video

Updated: Apr 17, 2026

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine
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Curcumin as a putative antidepressant.

Ho-Jun Seo1, Sheng-Min Wang, Changsu Han

  • 1Department of Psychiatry, The Catholic University of Korea, College of Medicine, Seoul, Korea.

Expert Review of Neurotherapeutics
|February 4, 2015
PubMed
Summary
This summary is machine-generated.

Curcumin shows potential antidepressant effects through various mechanisms, but current clinical trials indicate only a small, non-significant benefit for major depression. Further research is needed to confirm its therapeutic role.

Keywords:
antidepressantcurcumindepressionmechanism of action

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Antidepressant efficacy is often inadequate, driving research into novel therapeutic agents.
  • Curcumin, a natural compound, is being investigated for its potential mood-regulatory properties.
  • Understanding curcumin's mechanisms is crucial for evaluating its role in depression treatment.

Purpose of the Study:

  • To summarize the properties and mechanisms of action of curcumin.
  • To review preclinical and clinical evidence for curcumin's efficacy in depression.
  • To identify future research directions for curcumin in depression therapy.

Main Methods:

  • Literature review of curcumin's basic properties and mechanisms.
  • Analysis of preclinical studies (animal models) on curcumin and depression.
  • Evaluation of current randomized clinical trials (human studies) on curcumin for major depression.

Main Results:

  • Curcumin exhibits diverse antidepressant mechanisms, including effects on neurotransmitters, neurogenesis, and inflammatory pathways.
  • Preclinical studies suggest promising antidepressant-like effects.
  • Published randomized clinical trials show a small, non-significant benefit for major depression.

Conclusions:

  • Curcumin possesses multifaceted mechanisms that may contribute to antidepressant activity.
  • Current clinical evidence is insufficient to support curcumin as a standalone treatment for major depression.
  • More robust, well-designed clinical trials are essential to ascertain curcumin's therapeutic value.