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Updated: Apr 17, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Relationship between blood and bronchial submucosal eosinophilia and reticular basement membrane thickening in
Osama Eltboli1, Vijay Mistry, Bethan Barker
1Institute for Lung Health, Department of Infection, Immunity & Inflammation, University of Leicester, Leicester, UK; Department of Medicine, Faculty of Medicine, Benghazi University, Benghazi, Libya.
Abstract:
A sputum eosinophilia is observed in 10-40% of COPD subjects. The blood eosinophil count is a biomarker of sputum eosinophilia, but whether it is associated with bronchial submucosal eosinophils is unclear. In 20 COPD subjects and 21 controls we assessed the number of bronchial submucosal eosinophils and reticular basement membrane thickening and found these were positively correlated with the blood eosinophil percentage. In COPD, blood eosinophils are a good biomarker of bronchial eosinophilia and remodelling.
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