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Analysis of Cell Migration within a Three-dimensional Collagen Matrix
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Non-genomic androgen action regulates proliferative/migratory signaling in stromal cells

Marzia Di Donato1, Pia Giovannelli1, Gustavo Cernera1

  • 1Department of Biochemistry, Biophysics and General Pathology, II University of Naples , Naples , Italy.

Frontiers in Endocrinology
|February 4, 2015
PubMed

Insights

Androgen receptor (AR) signaling in prostate cancer (PCa) influences cell behavior. This review explores AR

Area of Science:

  • Oncology and Molecular Biology

Background:

  • Prostate cancer (PCa) is a leading cause of cancer death in men.
  • Androgen-deprivation therapy (ADT) is a primary treatment, but often fails due to maintained androgen receptor (AR) expression.
  • AR signaling pathways are complex, influencing cell growth and transformation.

Purpose of the Study:

  • To review the multifaceted role of the androgen receptor (AR) in regulating mesenchymal and transformed mesenchymal cells.
  • To elucidate how AR signaling impacts stromal cell functions in the context of prostate cancer.

Main Methods:

  • Literature review of studies investigating androgen receptor signaling pathways.
  • Analysis of AR's role in controlling proliferation and migration of stromal and mesenchymal cells.
  • Synthesis of findings related to AR's dual function in cell growth and movement.

Main Results:

  • Androgen receptor (AR) plays a dual role, capable of both stimulating and suppressing cell proliferation.
  • AR signaling is shown to suppress proliferation while promoting migration in stromal cells.
  • These findings highlight context-dependent functions of AR in cellular processes.

Conclusions:

  • The androgen receptor (AR) significantly influences stromal cell behavior, impacting cancer progression.
  • Understanding AR's complex roles in mesenchymal cells offers new therapeutic insights for prostate cancer.
  • Targeting AR signaling pathways may provide novel strategies to overcome ADT resistance in PCa.
Keywords:
androgen receptorfibroblastsfibrosarcomafilamin Agrowth suppressionmigration

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