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Updated: Apr 17, 2026

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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
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Gestational diabetes mellitus screening using the one-step versus two-step method in a high-risk practice
Summary
Screening for gestational diabetes mellitus (GDM) showed no difference in delivery or neonatal outcomes between one-step and two-step methods. However, the one-step approach had lower patient compliance with screening.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Endocrinology
Background:
- Screening protocols for gestational diabetes mellitus (GDM) are debated.
- Current guidelines offer various approaches to GDM screening.
Purpose of the Study:
- To compare delivery and neonatal outcomes between one-step and two-step GDM screening methods.
- To assess patient compliance with different GDM screening protocols.
Main Methods:
- Retrospective analysis of high-risk obstetrical patients.
- Comparison of outcomes based on one-step versus two-step GDM screening.
Main Results:
- No significant differences in delivery outcomes (e.g., Cesarean delivery rates) were observed between the one-step and two-step screening groups.
- No significant differences in neonatal outcomes (e.g., birth weight, Apgar scores) were found between the two screening methods.
- Lower compliance rates were reported for the one-step GDM screening method compared to the two-step method.
Conclusions:
- In high-risk populations, the choice between one-step and two-step GDM screening does not appear to impact key delivery or neonatal outcomes.
- The one-step screening approach may lead to reduced patient adherence.
- Further research may be needed to optimize GDM screening strategies for improved compliance and patient engagement.
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