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Related Experiment Video

Updated: Apr 17, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Ipilimumab-associated bilateral optic neuropathy.

Oliver L Yeh¹, Courtney E Francis

¹Department of Ophthalmology, University of Washington, Seattle, Washington.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society

|February 4, 2015

Summary

This summary is machine-generated.

Ipilimumab, a melanoma drug, can cause optic neuropathy. This case report details a patient experiencing bilateral optic neuropathy with disc edema while on this treatment.

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Area of Science:

Immunology
Ophthalmology
Oncology

Background:

Ipilimumab is a monoclonal antibody targeting CTLA-4, improving survival in metastatic melanoma.
Previous reports link ipilimumab to drug-induced uveitis.

Observation:

A patient treated with ipilimumab developed bilateral optic neuropathy.
The patient presented with disc edema.

Findings:

This case highlights a rare adverse event of ipilimumab therapy.
Optic neuropathy and disc edema are potential ocular side effects.

Implications:

Clinicians should monitor for ocular toxicity during ipilimumab treatment.
Early detection and management of ipilimumab-induced optic neuropathy are crucial for preserving vision.