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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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New forms of old drugs: improving without changing
Sofia Domingos1, Vânia André1,2, Sílvia Quaresma1
1Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.
The Journal of Pharmacy and Pharmacology
|February 5, 2015
Summary
Discover innovative solid forms of active pharmaceutical ingredients (APIs) to accelerate drug development. New API forms enhance bioavailability and pharmacokinetics, overcoming lengthy market approval times.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Drug Delivery
Background:
- Developing new drugs is a lengthy and costly process, often taking 10-15 years.
- Repurposing known active pharmaceutical ingredients (APIs) through novel solid forms offers a faster route to market.
- Enhancing API properties like bioavailability and pharmacokinetics is crucial for therapeutic efficacy.
Purpose of the Study:
- To present recent advancements in creating new solid forms of existing APIs.
- To explore strategies for improving API efficiency and therapeutic outcomes.
- To highlight successful examples and emerging technologies in API formulation.
Main Methods:
- Review of innovative strategies for developing new solid forms of APIs.
- Analysis of multicomponent crystal forms for altering API physicochemical properties.
- Exploration of API-ionic liquids (ILs), metal drug coordination, and bio-inspired metal-organic frameworks (BioMOFs) for drug storage and delivery.
Main Results:
- New solid forms of known APIs can significantly shorten drug development timelines.
- Multicomponent crystal forms demonstrate promise in improving solubility, stability, and dissolution rates.
- Emerging approaches like API-ILs and BioMOFs show potential for advanced drug formulation and delivery.
Conclusions:
- Innovative methods for utilizing well-known APIs are crucial for efficient drug discovery.
- Multicomponent crystal forms are a key achievement, optimizing API physicochemical properties.
- API-ILs and BioMOFs represent promising future directions for drug development and delivery systems.
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