Tonsillectomy among children with low baseline acute throat infection consultation rates in UK general practices: a cohort study
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Published on: November 6, 2019
Elizabeth Koshy1, Hilary Watt1, Vasa Curcin2
1Department of Primary Care and Public Health, Imperial College London, London, UK.
Insights
Tonsillectomy significantly reduced acute throat infection (ATI) consultations in children with low baseline rates over six years. However, the clinical benefit must be balanced against surgical risks.
Area of Science:
- Pediatric Otolaryngology
- Public Health Research
- Clinical Effectiveness Studies
Background:
- Recurrent acute throat infections (ATIs) impact children's quality of life and healthcare utilization.
- Tonsillectomy is a common intervention, but its long-term effectiveness in reducing ATI consultations, especially in low-risk populations, requires further investigation.
Purpose of the Study:
- To evaluate the effectiveness of tonsillectomy in decreasing acute throat infection (ATI) consultation rates over a 6-year follow-up period.
- To analyze the impact of tonsillectomy on children with initially low rates of acute throat infections.
Main Methods:
- Retrospective cohort study utilizing UK general practice data from the Clinical Practice Research Datalink.
- Inclusion of children aged 4-15 years with ≤3 ATI consultations in the 3 years prior to 2001 (baseline).
- Comparison of 450 children undergoing tonsillectomy with 13,442 children with an ATI consultation in 2001.
Main Results:
- Tonsillectomy led to a significant reduction in mean ATI consultation rates over 6 years, with a mean annual decrease of 0.6 consultations per child.
- Children undergoing tonsillectomy were significantly less likely to experience ≥3 ATI consultations during both the first 3-year and subsequent 3-year follow-up periods (adjusted ORs 0.12 and 0.24, respectively).
- The reduction in consultations was more pronounced in the initial 3 years post-surgery compared to the subsequent 3 years.
Conclusions:
- Tonsillectomy demonstrated a statistically significant reduction in acute throat infection consultation rates over a 6-year follow-up in children with low baseline ATI rates.
- The observed clinical benefit of tonsillectomy in this population is modest and necessitates careful consideration of potential surgical risks and complications.
Objective:
To investigate the effectiveness of tonsillectomy in reducing acute throat infection (ATI) consultation rates over 6 years' follow-up among children with low baseline ATI consultation rates.
Design:
Retrospective cohort study.
Setting:
UK general practices from the Clinical Practice Research Datalink.
Participants:
Children aged 4-15 years with ≤3 ATI consultations during the 3 years prior to 2001 (baseline). 450 children who underwent tonsillectomy (tonsillectomy group) and 13 442 other children with an ATI consultation (comparison group) in 2001.
Main Outcome Measures:
Mean differences in ATI consultation rates over the first 3 years' and subsequent 3 years' follow-up compared with 3 years prior to 2001 (baseline); odds of ≥3 ATI consultations at the same time points.
Results:
Among children in the tonsillectomy group, the 3-year mean ATI consultation rate decreased from 1.31 to 0.66 over the first 3 years' follow-up and further declined to 0.60 over the subsequent 3 years' follow-up period. Compared with children who had no operation, those who underwent tonsillectomy experienced a reduction in 3-year mean ATI consultations per child of 2.5 (95% CI 2.3 to 2.6, p<0.001) over the first 3 years' follow-up, but only 1.2 (95% CI 1.0 to 1.4, p<0.001) over the subsequent 3 years' follow-up compared with baseline, respectively. This equates to a mean reduction of 3.7 ATI consultations over a 6-year period and approximates to a mean annual reduction of 0.6 ATI consultations per child, per year, over 6 years' follow-up. Children who underwent tonsillectomy were also much less likely to experience ≥3 ATI consultations during the first 3 years' follow-up (adjusted OR=0.12, 95% CI 0.08 to 0.17) and the subsequent 3 years' follow-up (adjusted OR=0.24, 95% CI 0.14 to 0.41).
Conclusions:
Among children with low baseline ATI rates, there was a statistically significant reduction in ATI consultation rates over 6 years' follow-up. However, the relatively modest clinical benefit needs to be weighed against the potential risks and complications associated with surgery.
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