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Oxidative stress, NADPH oxidases, and arteries

Qi-An Sun, Marschall S Runge1, Nageswara R Madamanchi

  • 1Marschall S. Runge, MD PhD, Department of Medicine, 125 MacNider Hall, University of North Carolina, Chapel Hill, NC 27599-7005, USA,

Hamostaseologie
|February 5, 2015
PubMed

Insights

Cardiovascular diseases like heart attack and stroke are major health threats. Targeting nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) may help prevent these conditions by reducing oxidative stress.

Area of Science:

  • Cardiovascular Research
  • Oxidative Stress Biology
  • Molecular Medicine

Background:

  • Atherosclerosis, myocardial infarction, and stroke are leading causes of death globally.
  • Rising obesity and diabetes mellitus exacerbate the public health impact of cardiovascular diseases (CVD).
  • Oxidative stress is a key mechanistic factor linking various CVD risk factors.

Purpose of the Study:

  • To investigate the role of oxidative stress in cardiovascular diseases.
  • To explore the function of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) in vascular cells.
  • To assess the potential of targeting NADPH oxidase for CVD prevention.

Main Methods:

  • Utilizing animal models to study the interplay between oxidative stress and CVD.
  • Analyzing the expression and activity of NADPH oxidase components in vascular tissues.
  • Evaluating the impact of modulating NADPH oxidase on atherosclerosis and hypertension.

Main Results:

  • NADPH oxidases are critically important in the development of atherosclerosis and hypertension in animal models.
  • Vascular cells generate reactive oxygen species primarily through NADPH oxidase enzymes.
  • Emerging evidence highlights the significance of NADPH oxidases in cardiovascular pathology.

Conclusions:

  • NADPH oxidases play a crucial role in mediating vascular oxidative stress.
  • Tissue-specific expression of NADPH oxidase components offers potential therapeutic targets.
  • Targeting vascular oxidative stress via NADPH oxidase inhibition may be a viable strategy for CVD prevention.

Keywords:
Oxidative stressatherosclerosisdiabetes mellitushypertension

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