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Basic biological characterization of feline morbillivirus
Rie Koide1, Shoichi Sakaguchi, Takayuki Miyazawa
1Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan.
The Journal of Veterinary Medical Science
|February 5, 2015
Summary
Feline morbillivirus (FmoPV) is an emerging feline virus. This study details FmoPV
Area of Science:
- Veterinary Virology
- Emerging Infectious Diseases
- Feline Pathology
Background:
- Feline morbillivirus (FmoPV) is an emerging virus implicated in chronic nephritis in domestic cats.
- Limited information exists regarding the biological characteristics of FmoPV, hindering effective management and control strategies.
Purpose of the Study:
- To establish a quantitative assay for FmoPV.
- To characterize the stability and inactivation parameters of FmoPV.
Main Methods:
- Development of a quantitative assay using indirect immunofluorescence.
- Determination of viral titers over time.
- Assessment of FmoPV stability at 4°C and inactivation by heat treatments.
Main Results:
- A quantitative indirect immunofluorescence assay for FmoPV was successfully established.
- FmoPV demonstrated significant stability at 4°C, maintaining high titers for at least 12 days.
- Heat treatment at 60°C inactivated FmoPV within 10 minutes, and at 70°C within 2 minutes.
Conclusions:
- The established quantitative assay provides a reliable method for FmoPV titration.
- Understanding FmoPV's stability and heat inactivation profiles is crucial for developing effective virus isolation protocols.
- This research offers vital data for mitigating FmoPV infection risks in feline populations.
