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Oxygen-dependent phenotypic variation in group A streptococcus.

Chuan Chiang-Ni1, Siao-Ying Nian1, Jiunn-Jong Wu2

  • 1Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|February 5, 2015
PubMed
Summary
This summary is machine-generated.

Oxygen levels significantly influence Streptococcus pyogenes (group A Streptococcus) morphology. Hypermucoid variants are inhibited by oxygen, suggesting a role for oxygen-dependent variation in bacterial pathogenesis.

Keywords:
group A streptococcusmucoidoxygenphenotypic variation

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Area of Science:

  • Microbiology
  • Bacterial Pathogenesis
  • Molecular Biology

Background:

  • Phenotypic heterogeneity in Streptococcus pyogenes (group A Streptococcus, GAS) correlates with virulence.
  • Mutations in the covR/covS system enhance GAS virulence and lethality.
  • GAS exhibits phenotypic variation in vitro, but environmental triggers remain unclear.

Purpose of the Study:

  • To investigate if specific environmental signals trigger GAS morphology variation.
  • To determine if different GAS morphology variants are selected under specific environmental stresses.

Main Methods:

  • Cultured GAS968, an emm12-type isolate, under various conditions.
  • Analyzed changes in mucoid and hypermucoid colony ratios within the total bacterial population.

Main Results:

  • The ratio of mucoid to hypermucoid colonies of GAS968 varied significantly between aerobic and anaerobic conditions.
  • Oxygen was found to inhibit the morphology conversion of GAS968.
  • This inhibition was not due to repressed growth under aerobic conditions.

Conclusions:

  • Oxygen-dependent morphology variation in GAS968 may play a role in bacterial pathogenesis.
  • Phenotypic heterogeneity contributes to invasive GAS infections.