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Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications
Published on: December 8, 2016
"Patient blood management" in orthopaedic surgery
Fernando Canillas1, Susana Gómez-Ramírez2, José Antonio García-Erce3
1Servicio de Cirugía Ortopédica y Traumatología, Hospital Cruz Roja, Madrid, España.
Patient Blood Management (PBM) programs aim to reduce allogeneic blood transfusions (ABT) in orthopaedic and trauma surgery. This review examines PBM strategies, their effectiveness, and implementation barriers in this specialty.
Area of Science:
- Orthopaedic Surgery
- Trauma Surgery
- Anesthesiology
- Hematology
Background:
- Orthopaedic and trauma surgeries often result in substantial blood loss and postoperative anemia.
- Allogeneic blood transfusions (ABT) are frequently required but carry clinical, economic, and logistical drawbacks.
Purpose of the Study:
- To review the effectiveness and safety of Patient Blood Management (PBM) strategies in orthopaedic and trauma surgery (OTS).
- To identify barriers and requirements for implementing PBM programs in OTS.
Main Methods:
- Review of perioperative measures within PBM programs.
- Analysis of strategies including restrictive transfusion criteria, erythropoiesis stimulation, bleeding reduction, and autologous blood transfusion.
- Examination of PBM program implementation in the context of OTS.
Main Results:
- PBM programs offer a multidisciplinary approach to minimize ABT needs.
- Key PBM components include optimizing red blood cell mass, managing coagulopathy, and employing restrictive transfusion guidelines.
- Effectiveness and safety data for PBM in OTS are reviewed, alongside practical implementation considerations.
Conclusions:
- PBM programs are crucial for reducing reliance on ABT in orthopaedic and trauma surgery.
- Successful implementation requires addressing specific barriers and establishing clear requirements within the surgical specialty.
- Optimizing patient outcomes and resource utilization is a primary goal of PBM in OTS.
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Preparation:

