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Fever, jaundice and acute renal failure

Sam M O'Toole1, Neha Pathak2, Graham C Toms2

  • 1Department of Endocrinology, Newham University Hospital, Barts Health NHS Trust, London, UK samuel.otoole2@bartshealth.nhs.uk.

Clinical Medicine (London, England)
|February 5, 2015
PubMed

Insights

Weil's disease, a severe form of leptospirosis, can present with fever, jaundice, and acute kidney injury. Early diagnosis relies on understanding the disease's epidemiology and pathophysiology.

Area of Science:

  • Infectious Diseases
  • Nephrology
  • Epidemiology

Background:

  • Leptospirosis is an infectious disease with diverse clinical presentations, from mild flu-like symptoms to severe multi-organ failure.
  • Weil's disease represents a severe manifestation of leptospirosis, characterized by jaundice and renal impairment.

Observation:

  • A case of Weil's disease presented acutely with fever, jaundice, and acute renal failure.
  • The patient's presentation mimicked other conditions, underscoring the diagnostic challenge.

Findings:

  • A thorough patient history and understanding of leptospirosis epidemiology were crucial for diagnosis.
  • The pathophysiology of leptospira infection explains the observed clinical triad.

Implications:

  • Highlights the importance of considering leptospirosis in patients with fever, jaundice, and acute kidney injury.
  • Emphasizes the value of detailed history taking and epidemiological awareness in diagnosing uncommon infectious diseases.
  • Suggests that prompt diagnosis and management can prevent severe outcomes associated with Weil's disease.
Keywords:
LeptospirosisWeil’s diseaseacute renal failurefeverjaundice

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