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Outcome of Ocular Steroid Hypertensive Response in Children

Savleen Kaur1, Indu Dhiman, Sushmita Kaushik

  • 1Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Journal of Glaucoma
|February 5, 2015
PubMed

Insights

Steroid-induced ocular hypertension in children is a significant concern, but withdrawing steroids and using glaucoma medications effectively controlled high intraocular pressure in most cases. Early intervention and alternative treatments can prevent long-term vision damage.

Area of Science:

  • Ophthalmology
  • Pediatric Glaucoma
  • Steroid-induced Ocular Hypertension

Background:

  • Steroid use in children can lead to ocular hypertension, a condition characterized by elevated intraocular pressure (IOP).
  • Understanding the epidemiological profile and outcomes of this condition is crucial for effective management in pediatric populations.

Purpose of the Study:

  • To analyze the epidemiological characteristics and treatment outcomes of steroid-induced ocular hypertension in children under 12 years old.
  • To identify risk factors and effective management strategies for pediatric steroid-induced ocular hypertension.

Main Methods:

  • Retrospective review of hospital records of pediatric glaucoma patients from July 2005 to December 2012.
  • Definition of steroid-induced ocular hypertension: IOP > 21 mm Hg or > 6 mm Hg increase from baseline, with or without glaucomatous optic neuropathy.
  • Data collected included demographics, steroid use, management details, and IOP control.

Main Results:

  • Steroid-induced ocular hypertension accounted for 24% of pediatric glaucoma cases (36 of 150 patients).
  • The mean age of affected children was 9.2 ± 2.4 years, with 22 patients showing a bilateral response.
  • Steroid withdrawal alone managed 16 patients, medical therapy controlled 13, and 7 required surgery. Favorable IOP control (<21 mm Hg) was achieved in 80.5% of cases.

Conclusions:

  • Steroid-induced ocular hypertension is a notable side effect in pediatric patients.
  • Non-steroidal anti-inflammatory alternatives should be considered to avoid steroid use when possible.
  • Withdrawal of steroids and appropriate medical management are effective in controlling IOP in the majority of affected children.
Abstract

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