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Adrenergic mediated phosphatidylinositol metabolism is modulated by epileptic discharges in human neocortex
1Montreal Neurological Institute, McGill University, Que, Canada.
Brain Research
|February 27, 1989
Abstract:
Adrenergic mediated phosphatidylinositol (PI) hydrolysis was measured in tissues obtained from 21 patients immediately following surgery for focal epilepsy. Accumulation of [3H]inositol monophosphate (IP1) was significantly reduced (21%, P less than 0.01) in actively spiking neocortex (n = 15) versus samples from non-spiking regions (n = 9). Epileptic discharges may blunt alpha 1-adrenoceptor stimulated transmembrane signalling in human neocortical epileptic foci.