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Updated: Apr 17, 2026

Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts
Published on: April 26, 2018
A GGCT fluorogenic probe: design, synthesis and application to cancer-related cells
Taku Yoshiya1, Hiromi Ii, Shugo Tsuda
1Peptide Institute, Inc., Ibaraki, Osaka 567-0085, Japan. t.yoshiya@peptide.co.jp yuji@peptide.co.jp.
Abstract:
Cancer-related γ-glutamyl cyclotransferase (GGCT) specifically converts γ-glutamyl amino acids (γ-Glu-Xaa) into pyroglutamate and the corresponding amino acids (Xaa). Here we report a novel GGCT fluorogenic probe "LISA-101" containing a masked O-acylated fluorophore "resorufin" on the side chain of the P amino acid (Xaa). Upon GGCT treatment, the P amino acid was liberated and spontaneously released the intact fluorophore. Thus, the fluorescence was regained. LISA-101 will expand the strategies for cancer studies.
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