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Anorexia nervosa and body dysmorphic disorder are associated with abnormalities in processing visual information
1Interdepartmental Neuroscience Program,University of California,Los Angeles,CA,USA.
Psychological Medicine
|February 6, 2015
Summary
Individuals with anorexia nervosa (AN) and body dysmorphic disorder (BDD) show similar visual processing abnormalities. These findings suggest a shared neural basis for perceptual distortions in AN and BDD.
Area of Science:
- Neuroscience
- Psychiatry
- Visual Perception
Background:
- Anorexia nervosa (AN) and body dysmorphic disorder (BDD) share distorted body image and are often comorbid.
- Previous research indicates visual processing abnormalities in AN and BDD, but direct comparisons are lacking.
- Early visual signaling abnormalities were investigated using event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI).
Purpose of the Study:
- To directly compare visual processing abnormalities in individuals with anorexia nervosa (AN) and body dysmorphic disorder (BDD).
- To investigate early visual signaling differences between AN, BDD, and healthy controls using ERPs and fMRI.
Main Methods:
- fMRI and ERP data were collected from 15 unmedicated individuals in each of three groups: weight-restored AN, BDD, and healthy controls.
- Participants viewed images of faces and houses at different spatial frequencies.
- Joint independent component analyses were used to compare activity in visual systems.
Main Results:
- Both AN and BDD groups exhibited hypoactivity in visual processing regions and the dorsal visual stream when viewing low spatial frequency faces (N170 component).
- Hypoactivity was also observed in early secondary visual processing regions for low spatial frequency houses (P100 component) in both AN and BDD groups.
- The BDD group showed hyperactivity in the fusiform cortex for high spatial frequency houses (N170 component), linked to lower attractiveness ratings.
Conclusions:
- Preliminary evidence suggests similar abnormal spatiotemporal activation in AN and BDD for processing both appearance-related and non-appearance-related stimuli.
- These findings indicate a potential common phenotype of abnormal early visual system functioning in AN and BDD.
- This shared visual processing abnormality may contribute to the perceptual distortions characteristic of these disorders.
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