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The stability and short-term fluctuation in serum oxytocinase activity in pregnancy
A A Edebiri1, D S Mack, D J McDonald
1Department of Obstetrics, Rutherglen Maternity Hospital, Glasgow, UK.
Abstract:
Maternal serum samples obtained from 123 normal pregnant women between 28 and 40 weeks gestation were analysed for oxytocinase (EC 3.4.11.3) activity using s-benzyl-1-cysteine-4-nitroanilide as substrate. Oxytocinase activity was found to be stable at varying temperatures, with a mean co-efficient of variation of 5.0%. The short-term fluctuation of oxytocinase activity had a mean coefficient of variation of 3.6%. There is no suggestion of a "pulsatile" release of oxytocinae from its placental origin.
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