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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
Published on: October 4, 2019
MicroRNAs in pediatric central nervous system embryonal neoplasms: the known unknown
Maria Braoudaki1,2, George I Lambrou3
1First Department of Pediatrics, University of Athens, Choremeio Research Laboratory, Athens, Greece. mbraoudak@med.uoa.gr.
Abstract:
MicroRNAs (miRNAs) are endogenous short non-coding RNAs that repress post-transcriptional regulation of gene expression, while embryonal central nervous system tumors are the foremost cause of mortality in children suffering from a neoplasm. MiRNAs and their regulatory mechanisms are new to understand, while pediatric CNS tumors are difficult to comprehend. Therefore, identification of the link between them composes a major scientific challenge. The present study, reviewed the current knowledge on the role of miRNA in pediatric CNS embryonal tumors, attempting to collect the existing information in one piece of work that could ideally be used as a guide for future reference and research.
Insights
MicroRNAs (miRNAs) regulate gene expression and are implicated in pediatric central nervous system (CNS) embryonal tumors, a leading cause of cancer mortality in children. This review consolidates current knowledge on miRNA roles in these challenging tumors for future research.
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- MicroRNAs (miRNAs) are crucial regulators of gene expression at the post-transcriptional level.
- Pediatric central nervous system (CNS) embryonal tumors are a significant cause of cancer-related mortality in children.
- Understanding the complex interplay between miRNAs and pediatric CNS tumors presents a substantial scientific challenge.
Purpose of the Study:
- To review and consolidate current knowledge on the role of miRNAs in pediatric CNS embryonal tumors.
- To provide a comprehensive resource for researchers investigating miRNA involvement in these neoplasms.
- To identify gaps in current understanding and guide future research directions.
Main Methods:
- Systematic literature review of studies investigating miRNA expression and function in pediatric CNS embryonal tumors.
- Analysis of existing data on miRNA regulatory networks within these tumor types.
- Synthesis of findings to establish the current state of knowledge.
Main Results:
- miRNAs play diverse roles in the development and progression of pediatric CNS embryonal tumors.
- Specific miRNA signatures are associated with different subtypes and prognoses of these tumors.
- Dysregulation of miRNA pathways contributes to the pathogenesis of pediatric CNS embryonal tumors.
Conclusions:
- miRNAs represent promising diagnostic and therapeutic targets for pediatric CNS embryonal tumors.
- Further research is needed to fully elucidate miRNA functions and therapeutic potential in this field.
- This review serves as a foundational guide for future investigations into miRNA-mediated mechanisms in pediatric CNS embryonal tumors.
