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Ginseng: a promising neuroprotective strategy in stroke
Vaibhav Rastogi1, Juan Santiago-Moreno2, Sylvain Doré3
1Departments of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine Gainesville, FL, USA ; Departments of Neurology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine Gainesville, FL, USA.
Ginseng (Panax Ginseng) shows neuroprotective effects, potentially treating stroke by reducing inflammation and oxidative stress. Further clinical trials are needed to confirm its benefits for neurological disorders.
Area of Science:
- Neuroscience
- Pharmacology
- Herbal Medicine
Background:
- Ginseng (Panax Ginseng) is a widely used traditional herbal medicine, particularly in Asian countries.
- It has a long history of use for various ailments and immune support.
- Ginseng is recognized for its potential therapeutic applications in neurological disorders.
Purpose of the Study:
- To review the neuroprotective effectiveness of ginseng, with a specific focus on stroke.
- To highlight the mechanisms underlying ginseng's putative efficacy in neurological conditions.
- To identify areas requiring further research and clinical validation.
Main Methods:
- Comprehensive literature search on ginseng's neuroprotective effects.
- Analysis of in vitro and in vivo studies.
- Focus on randomized controlled clinical trials for practical applications.
Main Results:
- Ginseng may protect against stroke by maintaining homeostasis.
- Neuroprotection is linked to the attenuation of inflammation and suppression of oxidative stress.
- Activation of Nrf2 (cytoprotective transcriptional factor) contributes to reduced reactive oxygen species and neuronal protection.
Conclusions:
- Ginseng demonstrates potential in preventing neuronal death and reducing stroke-related damage.
- Mechanisms include anti-inflammatory and antioxidant properties, notably via Nrf2 activation.
- More extensive in vitro, in vivo, and clinical studies are essential to fully understand ginseng's therapeutic potential for neurological disorders.
