The relationship between serum adiponectin and inflammatory cytokines in obese Korean juveniles
Sung Hwan Byun1, Eun Byul Kwon1, Se Young Kim1
1Department of Pediatrics, Bundang Jesaeng Hospital, Seongnam, Korea.
Insights
In obese children and adolescents, lower adiponectin levels correlate with higher inflammation markers like ICAM-1. This suggests adiponectin may indicate inflammatory status in pediatric obesity.
Area of Science:
- Pediatric Endocrinology
- Cardiovascular Health
- Inflammation Research
Background:
- Obesity is linked to systemic inflammation and cardiovascular risks.
- Intercellular adhesion molecule-1 (ICAM-1), CD40 ligand (CD40L), and P-selectin are key inflammatory mediators in atherosclerosis.
- Adiponectin exhibits anti-inflammatory properties in adults.
Purpose of the Study:
- To investigate the relationship between adiponectin and inflammatory mediators in children and adolescents.
- To compare inflammatory markers in obese versus non-obese pediatric populations.
Main Methods:
- Study included 50 children/adolescents: 22 obese (BMI >95th percentile) and 28 non-obese (BMI <75th percentile).
- Measured serum levels of adiponectin, soluble ICAM-1 (sICAM-1), P-selectin, CD40L, lipids, liver enzymes, glucose, and insulin.
- Analyzed associations between adiponectin and inflammatory markers, comparing obese and non-obese groups.
Main Results:
- Obese participants had significantly lower adiponectin and higher sICAM-1 compared to non-obese.
- No significant differences in P-selectin or soluble CD40L were observed between groups.
- Adiponectin showed a negative association with ICAM-1 and P-selectin in the obese group.
Conclusions:
- Lower adiponectin levels in obese children and adolescents are associated with increased ICAM-1 and P-selectin.
- Serum adiponectin may serve as a marker for inflammatory status in pediatric obesity.
- Findings highlight the role of adiponectin in the inflammatory processes associated with childhood obesity.
Purpose:
Obesity is related to systemic inflammatory processes causing cardiovascular complications. Intercellular adhesion molecule-1 (ICAM-1), CD40 ligand (CD40L), P-selectin are newly described mediators of inflammation and have a significant effect in atherosclerosis. Adiponectin has shown anti-inflammatory effects in adults. The aim of this study was to evaluate the relationship between adiponectin and inflammatory mediators in children and adolescents.
Methods:
Fifty children or adolescents, twenty two with a body mass index (BMI) over 95th percentile, and twenty eight with a BMI below 75th percentile were included in the study. Serum soluble ICAM-1 (sICAM-1), P-selectin, CD40L, lipid profiles, aspartate aminotransferase, alanine aminotransferase, glucose and insulin were measured to evaluate associations with adiponectin. Comparison of these variables was performed between the obese and the nonobese group.
Results:
We found a adiponectin to be significant lower and sICAM-1 significant higher in the obese group compared to the nonobese group, but there were no significant differences in P-selectin and soluble CD40L. Adiponectin was negatively associated with ICAM-1 and P-selectin in the obese group.
Conclusion:
Negative associations of adiponectin with ICAM-1 and P-selectin in obese children and adolescents suggest that serum adiponectin level may represent the inflammatory status.
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