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The vesicle-associated function of NOD2 as a link between Crohn's disease and mycobacterial infection

Alexey A Nabatov1

  • 1Maastricht Radiation Oncology, MAASTRO/GROW Maastricht University Medical Center+, PO Box 616, 6200 MD Maastricht, The Netherlands ; Science Center, Volga Region State Academy of Physical Culture, Sport and Tourism, 33, Universiade Village, Kazan, 420138 Russia.

Gut Pathogens
|February 6, 2015
PubMed

Insights

Crohn's disease (CD) may involve Mycobacterium avium subsp. paratuberculosis (MAP). New findings suggest the NOD2 gene plays a key role in both CD and MAP infections, offering new treatment avenues.

Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiology

Background:

  • The etiology of Crohn's disease (CD) is not fully understood.
  • Evidence suggests an infectious component in CD pathogenesis.
  • Mycobacterium avium subsp. paratuberculosis (MAP) is a potential causative agent.

Purpose of the Study:

  • To elucidate the molecular mechanisms linking MAP to CD pathogenesis.
  • To explore the role of NOD2 gene polymorphism in CD and mycobacterial infections.
  • To integrate recent findings on NOD2 function into a cohesive model.

Main Methods:

  • Review and synthesis of recent research on NOD2 interactions and functions.
  • Analysis of the genetic predisposition associated with NOD2.
  • Comparative analysis of mechanisms in mycobacterial infections and CD.

Main Results:

  • NOD2 gene polymorphism is a known risk factor for CD and mycobacterial infections.
  • Recent discoveries illuminate NOD2's role as an intracellular pattern recognition receptor.
  • These findings provide a mechanistic link between NOD2, MAP, and CD.

Conclusions:

  • A NOD2-mediated mechanism common to mycobacterial infections and CD is proposed.
  • Understanding this mechanism can lead to improved diagnostics and therapeutics for CD.
  • Further research into NOD2 pathways may yield novel treatments for both CD and mycobacterial diseases.
Keywords:
AutophagyCrohn’s diseaseMycobacteriaPattern recognition receptorsSulfonated glycolipidsVesicle acidity

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