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Tyrosine hydroxylase and levodopa responsive dystonia
N A Fletcher1, I J Holt, A E Harding
1Department of Clinical Neurology, Institute of Neurology, London, UK.
Journal of Neurology, Neurosurgery, and Psychiatry
|January 1, 1989
Abstract:
It has been suggested that a form of inherited dystonia responsive to levodopa might be due to an abnormality of tyrosine hydroxylase gene. This hypothesis has been tested using a cDNA tyrosine hydroxylase gene probe in three families with this disorder. No evidence for genetic linkage between the disease and tyrosine hydroxylase loci was found; it is possible that the disorder results from a post-transcriptional defect confined to the brain.