Dermatoglyphics and karyotype analysis in primary amenorrhoea

Area of Science:

• Genetics and Human Biology
• Dermatoglyphics
• Reproductive Health

Background:

• Dermatoglyphics analyzes skin ridge patterns for diagnostic support in genetic disorders.
• Primary amenorrhoea is suspected to have multifactorial genetic and environmental causes.
• Investigating dermatoglyphic traits may offer insights into the etiology of primary amenorrhoea.

Purpose of the Study:

• To examine finger dermatoglyphic patterns in primary amenorrhoea cases.
• To compare these patterns with age-matched fertile control females.
• To determine if specific dermatoglyphic traits are statistically significant in primary amenorrhoea.

Main Methods:

• A comparative study involving 30 primary amenorrhoea cases and 30 fertile controls.
• Analysis of fingertip dermatoglyphic patterns in all participants.
• Karyotype assessment for primary amenorrhoea cases.

Main Results:

• Two primary amenorrhoea subjects presented with abnormal karyotypes.
• A statistically significant increase in total finger ridge count (TFRC) was observed in primary amenorrhoea cases.
• Higher frequencies of loop and arch patterns were noted in primary amenorrhoea cases with abnormal karyotypes.

Conclusions:

• Increased TFRC and altered pattern frequencies (loops, arches) are significant dermatoglyphic findings in primary amenorrhoea.
• Dermatoglyphics can serve as a supportive investigation for identifying predisposition to primary amenorrhoea.
• These findings support the utility of dermatoglyphics in recommending karyotyping for individuals with primary amenorrhoea.