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Updated: Sep 27, 2026

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
A rare case report of clear cell variant of oral squamous cell carcinoma
Purshotam Nainani1, Harkanwal Preet Singh2, Aparna Paliwal3
1Professor and Head, Department of Oral Pathology, RKDF Dental College , Bhopal, M.P, India .
Abstract:
Clear cell squamous cell carcinoma (SCC) is an extremely rare heterogenous group of malignant tumour with incompletely understood aetiology. We, hereby present a case of clear cell variant of squamous carcinoma on buccal mucosa in 52-year-old male patient. Histopathology showed sheets of squamous cells with clear cell differentiation and malignant features. Histochemical findings showed negative staining for Periodic Acid-Schiff (PAS), mucicarmine and Oil Red O. Immunohistochemical investigations revealed positive staining for CK 8-18 and negative for S-100. We conclude by emphasizing on the need of careful analysis of all the histopathological and IHC investigations. To predict the exact prognosis of this rare variant more number of case reports are expected to be published in future.
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