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Synthesis and dopaminergic activity of 2-substituted octahydrobenzo[f]quinolines
J C Craig1, S M Torkelson, P R Findell
1Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco 94143.
Journal of Medicinal Chemistry
|May 1, 1989
Abstract:
A series of 2-substituted octahydrobenzo[f]quinolines has been synthesized and assayed for dopamine agonist activity. Only the compounds corresponding to the beta-rotameric conformation of dopamine showed biphasic activity in competition binding studies with the radioligand [3H]spiroperidol. These findings suggest that the congeners possessing the beta-rotamer conformation show receptor-binding characteristics that resemble those of the ergolines more closely than do those of the corresponding alpha-rotamer congeners.