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Predisposition to familial osteoarthrosis linked to type II collagen gene
1Laboratory of Molecular Genetics, National Public Health Institute, Helsinki, Finland.
Lancet (London, England)
|April 29, 1989
Abstract:
The genetic background of two families, in whom a predisposition to primary osteoarthrosis is inherited as a dominant trait, was investigated. Use of restriction fragment length polymorphisms within and around the type II collagen gene on chromosome 12 revealed a linkage between this cartilage-specific gene and primary osteoarthrosis.