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Updated: Apr 17, 2026

HUVEC Tube-formation Assay to Evaluate the Impact of Natural Products on Angiogenesis
Published on: June 24, 2019
Marine and soil derived natural products: a new source of novel cardiovascular protective agents targeting the
Nadir Planes1, Catherina Caballero-George1
1Institute for Scientific Research and High Technology Services, City of Knowledge, Clayton, Panama, Republic of Panama.
Abstract:
Inhibition of the endothelin system is a recognized therapeutic approach for treating complex cardiovascular diseases. The search for natural inhibitors of the endothelin system has focused mainly on land, with recent, emerging data suggesting the underestimated potential of marine microorganisms for producing leads with cardioprotective potential. The present work reviews natural products identified as inhibitors of the endothelin system, their origin, their mechanism of action, and their ecological significance.
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