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Updated: Aug 14, 2026
08:08
Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
Published on: June 18, 2013
Evidence for fatty acid transfer across the human placenta
Ciba Foundation Symposium
|March 1, 1978
Summary
Fatty acids transfer across the human placenta, with maternal free fatty acid and triglyceride levels influencing fetal blood flow. This research confirms placental fatty acid transport mechanisms.
Area of Science:
- Obstetrics and Gynecology
- Human Physiology
- Biochemistry
Background:
- Understanding nutrient transfer to the fetus is crucial for prenatal health.
- The placenta's role in transporting lipids, particularly fatty acids, is a key area of research.
Purpose of the Study:
- To investigate the transfer of fatty acids across the human placenta.
- To determine how maternal lipid concentrations affect fetal lipid supply.
Main Methods:
- Lipid analysis of umbilical artery and vein blood.
- Experiments utilizing artificially perfused human placentas.
- Measurement of fetal blood triglyceride concentrations and essential fatty acid percentages in fetal adipose tissue.
Main Results:
- Evidence supports the transfer of fatty acids from mother to fetus via the placenta.
- Maternal blood concentrations of free fatty acids and triglycerides directly influence the flow of these lipids to the fetus.
Conclusions:
- Fatty acids are confirmed to cross the human placenta.
- Maternal lipid status is a significant determinant of fetal fatty acid availability.
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