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Related Experiment Videos

[Kidney tubule dysfunction caused by acetic acid].

G H Schardijn, J J Kastelein, L W Statius van Eps

    Nederlands Tijdschrift Voor Geneeskunde
    |March 18, 1989
    PubMed
    Summary

    Ingestion of 80% acetic acid can cause kidney damage, including tubular proteinuria and potential proximal tubule toxicity. Treatment involved nasogastric feeding and parenteral nutrition, with recovery observed in both patients.

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    Area of Science:

    • Toxicology
    • Nephrology
    • Internal Medicine

    Background:

    • Acetic acid ingestion is a rare but serious clinical event.
    • Understanding the renal effects of concentrated acetic acid is crucial for patient management.

    Observation:

    • Two patients ingested 80% acetic acid, presenting with varying degrees of renal injury.
    • One patient experienced hemolysis, intravascular coagulation, and oliguric kidney insufficiency.
    • Both patients exhibited elevated urinary excretion of kidney injury biomarkers (beta 2-microglobulin, alanine-aminopeptidase, N-acetyl-glucosaminidase) and tubular proteinuria.

    Findings:

    • The second patient's presentation suggests a direct toxic effect of acetic acid on renal proximal tubules.
    • Elevated biomarker excretion normalized over time, indicating potential renal recovery.
    • Hemodynamic stability and absence of fever were noted in both cases.

    Implications:

    • Highlights the nephrotoxic potential of concentrated acetic acid.
    • Emphasizes the importance of monitoring renal function and specific biomarkers after ingestion.
    • Suggests that prompt supportive care may lead to recovery from acute kidney injury induced by acetic acid.

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