Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

71
Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
71

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Directed Evolution of an Efficient Polycarbonate Depolymerase With Exceptional Operational Stability.

Angewandte Chemie (International ed. in English)·2026
Same author

Proton sponge: an aromatic glycolysis catalyst.

RSC advances·2026
Same author

Enhanced enzymatic hydrolysis of pretreated polyester textile at high solids loading through fusion with a carbohydrate binding module.

Bioresource technology·2026
Same author

Chemical Recycling of Polycarbonate Acrylonitrile Butadiene Styrene Blends via Organocatalyzed Acetolysis.

ChemSusChem·2026
Same author

Cyclic carbamates from epoxides and isocyanates catalysed by inorganic salts.

RSC advances·2025
Same author

The link of carbon catabolite repression elements, small RNAs CrcY and CrcZ and polyhydroxyalkanoate metabolism in Pseudomonas putida KT2440.

Biotechnology for biofuels and bioproducts·2025

Related Experiment Video

Updated: Apr 17, 2026

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.7K

Micro- and nano-structure based oligonucleotide sensors.

David C Ferrier1, Michael P Shaver2, Philip J W Hands1

  • 1School of Engineering, University of Edinburgh, Edinburgh EH9 3JL, UK.

Biosensors & Bioelectronics
|February 7, 2015
PubMed
Summary

Micro- and nano-structure biosensors offer robust, portable, and commercially viable methods for oligonucleotide detection. These advanced techniques are ideal for point-of-care diagnostics and on-site testing applications.

Keywords:
BiosensorDNADetectionMEMSNEMSOligonucleotide

More Related Videos

A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

8.5K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

12.3K

Related Experiment Videos

Last Updated: Apr 17, 2026

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.7K
A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

8.5K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

12.3K

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Biosensing

Background:

  • Micro- and nano-structure based devices are highly suitable for biosensing applications due to their small scale, robustness, portability, and compatibility with CMOS electronics.
  • These characteristics facilitate integration into hand-held devices and enable mass production, making them commercially viable for oligonucleotide detection.
  • The review focuses on the advantages of these micro- and nano-scale sensors for Point-of-Care (POC) or On-Site-Testing (OST) applications.

Purpose of the Study:

  • To review micro- and nano-structure based techniques for oligonucleotide detection and quantification.
  • To highlight the advantages of these sensors for Point-of-Care and On-Site-Testing applications.
  • To discuss various developed oligonucleotide detection methods and immobilization techniques.

Main Methods:

  • Review of existing literature on micro- and nano-structure based oligonucleotide detection.
  • Discussion of sensor types including Bulk Acoustic Wave (BAW), Surface Acoustic Wave (SAW), micro- and nano-cantilevers, gene Field Effect Transistors (gFETs), nanowire, and nanopore sensors.
  • Exploration of oligonucleotide immobilization strategies.

Main Results:

  • Micro- and nano-structure sensors offer significant advantages in terms of portability, robustness, and potential for mass production.
  • Various techniques like BAW, SAW, cantilevers, gFETs, nanowires, and nanopores show promise for sensitive oligonucleotide detection.
  • Oligonucleotide immobilization is a critical factor for sensor performance and is discussed in the context of these micro- and nano-devices.

Conclusions:

  • Micro- and nano-structure based sensors are highly attractive for commercialization in oligonucleotide detection.
  • These technologies are well-suited for developing portable and robust biosensing devices for Point-of-Care and On-Site-Testing.
  • Further development and application of these micro- and nano-scale sensing platforms are expected to advance diagnostic capabilities.