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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
11.8K
Management of the marginal zone lymphomas
Barbara Vannata1, Anastasios Stathis, Emanuele Zucca
1Lymphoma Unit, Oncology Institute of Southern Switzerland, Ospedale San Giovanni, 6500, Bellinzona, Switzerland.
Cancer Treatment and Research
|February 7, 2015
Summary
Marginal zone lymphomas (MZL) are linked to chronic inflammation and infections. Eradicating Helicobacter pylori can lead to regression of gastric MZL, but other causes and treatments are less clear.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Marginal zone lymphomas (MZL) constitute approximately 8% of non-Hodgkin lymphomas.
- Extranodal MZL often develops at mucosal sites due to chronic inflammation, autoimmune conditions, or infections.
- Persistent antigenic stimulation can lead to genetic abnormalities, resulting in MALT lymphoma development.
Purpose of the Study:
- To review recent advances in the understanding, diagnosis, staging, and management of Marginal Zone Lymphomas.
- To explore the etiopathogenetic links between chronic conditions and MZL development.
- To discuss the role of antimicrobial therapy in MZL treatment.
Main Methods:
- Literature review of studies on MZL pathogenesis, diagnosis, and treatment.
- Analysis of the association between specific microbial agents and MZL subtypes.
- Evaluation of treatment outcomes, particularly antimicrobial therapy efficacy.
Main Results:
- Strong evidence links Helicobacter pylori infection to gastric MALT lymphoma, with successful eradication leading to regression in over two-thirds of cases.
- Other microbes like Borrelia burgdorferi, Chlamydophila psittaci, and Campylobacter jejuni are implicated in MZL of the skin, ocular adnexa, and small intestine, respectively.
- Hepatitis C virus (HCV) prevalence is higher in MZL patients, suggesting a potential role, though antimicrobial therapy efficacy is less defined for non-gastric MZL and splenic MZL.
Conclusions:
- Chronic antigenic stimulation is a key factor in MZL pathogenesis.
- Antimicrobial therapy, particularly for H. pylori, is effective for gastric MALT lymphoma.
- Further research is needed to clarify the role of infections and optimize treatment strategies for other MZL subtypes.
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