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Published on: November 1, 2024
Peripapillary choroidal thickness in young Asians with high myopia
Preeti Gupta1, Carol Y Cheung2, Seang-Mei Saw2
1Singapore Eye Research Institute and Singapore National Eye Centre, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
Highly myopic eyes exhibit thinner peripapillary choroid compared to emmetropic eyes. Axial length, intraocular pressure, posterior staphyloma, and chorioretinal atrophy are key predictors of this thickness variation.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Myopia Research
Background:
- High myopia is a growing global health concern.
- Understanding the structural characteristics of the peripapillary choroid is crucial for managing myopic complications.
- Peripapillary choroidal thickness (PPCT) variations may indicate ocular health status.
Purpose of the Study:
- To investigate the topography and predictors of peripapillary choroidal thickness (PPCT) in young, healthy Asian individuals with high myopia.
- To compare PPCT in high myopic eyes versus emmetropic eyes.
Main Methods:
- Utilized enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT) for choroidal imaging.
- Recruited 870 young male subjects from the Singapore military.
- Manually measured PPCT at eight locations around the optic disc in 448 high myopes and 116 emmetropes.
Main Results:
- High myopic eyes (mean SE -8.52 ± 1.20 D) had significantly thinner peripapillary choroid (142.62 ± 43.84 μm) than emmetropic eyes (181.90 ± 46.43 μm).
- PPCT decreased with increasing myopic refractive error and showed different topographical distributions between high myopes (thickest superiorly) and emmetropes (thickest temporally).
- Axial length, intraocular pressure (IOP), posterior staphyloma, and chorioretinal atrophy were significantly associated with PPCT.
Conclusions:
- Highly myopic eyes demonstrate significantly thinner peripapillary choroid with distinct thickness distribution compared to emmetropic eyes.
- Axial length, IOP, posterior staphyloma, and chorioretinal atrophy are significant factors influencing PPCT.
- These predictors are important for clinical interpretation of PPCT measurements in myopia.
