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Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
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Quantifying Intracranial Aneurysm Wall Permeability for Risk Assessment Using Dynamic Contrast-Enhanced MRI: A Pilot

P Vakil1, S A Ansari2, C G Cantrell3

  • 1From the Departments of Radiology (P.V., S.A.A., J.V., M.C.H., T.J.C.) Biomedical Engineering (P.V., C.G.C., T.J.C.), Northwestern University, Chicago, Illinois.

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Summary
This summary is machine-generated.

This study shows that measuring contrast agent permeability (Ktrans) in intracranial aneurysms using dynamic contrast-enhanced MR imaging can help assess rupture risk. Higher permeability correlates with aneurysm size and other risk factors, aiding clinical decisions.

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Area of Science:

  • Neuroradiology
  • Medical Imaging
  • Vascular Biology

Background:

  • Pathological changes in intracranial aneurysm walls can increase permeability.
  • The clinical significance of aneurysm wall permeability for rupture risk is not well understood.
  • This pilot study explores aneurysm wall permeability as a novel marker for rupture risk.

Purpose of the Study:

  • To quantify intracranial aneurysm wall permeability (Ktrans, VL) to contrast agent.
  • To assess aneurysm wall permeability as a measure of aneurysm rupture risk.
  • To compare permeability parameters with established clinical and anatomic risk factors.

Main Methods:

  • Dynamic contrast-enhanced MR imaging was used in 27 unruptured intracranial aneurysms from 23 patients.
  • Wall permeability parameters (Ktrans, VL) were measured and compared to control MCA.
  • Parameters were evaluated against clinical (symptomatic lesions) and anatomic (size, location, morphology) risk metrics.

Main Results:

  • High interobserver agreement for Ktrans measurements (ICC > 0.92).
  • Significantly increased wall permeability in aneurysms compared to healthy MCA (P < .001).
  • Ktrans correlated with aneurysm size (P < .001) and predicted risk independent of size in anatomic and combined risk groups.

Conclusions:

  • This is the first study to model contrast permeability in intracranial aneurysms using DCE-MRI.
  • Aneurysm wall permeability significantly correlates with aneurysm size and size-independent anatomic risk factors.
  • Ktrans is a significant, size-independent predictor of high-risk aneurysms based on morphology and clinical factors.