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An alpha 2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man
E Palazidou1, A Papadopoulos, A Sitsen
1Institute of Psychiatry, London, UK.
Psychopharmacology
|January 1, 1989
Abstract:
Nocturnal plasma melatonin concentration was significantly increased in ten normal volunteers following the administration of an alpha 2 adrenoceptor antagonist, Org 3770 (30 mg). This result supports the existence of an alpha 2 adrenergic influence on melatonin secretion in man and provides a possible clinical neuroendocrine marker of the action of an alpha 2 antagonist.