[Neurohumoral and immune homeostasis in experimental toxoplasmosis in white rats]

The intraperitoneal inoculation of Toxoplasma gondii strain RH into white rats is accompanied by the disorganization of choline-and histamine-energic activity, which, on one hand, facilitates the spread of the infective agent throughout the body and, on the other hand, activates nonspecific and specific protective factors. The toxoplasmic antigen appears in the blood stream as early as 24 hours after inoculation. Its penetration into tissues coincides with the activation of complement, this activation first following the alternative pathway and then, after the appearance of antibodies, the classical pathway. The increase of the titers of specific antibodies favors the formation of subcompensation in the acetylcholine and histamine systems and is accompanied by the elimination of the parasites from internal organs and their migration to the brain. Such complex immunological investigations provide useful information making it possible to explain some specific features of the pathogenesis of toxoplasmosis.