Related Experiment Video
Updated: Apr 17, 2026
15:39
Studying Organelle Dynamics in B Cells During Immune Synapse Formation
Published on: June 1, 2019
9.7K
Dynamics of B cells in germinal centres
Nilushi S De Silva1, Ulf Klein1
1Herbert Irving Comprehensive Cancer Center and Departments of Pathology and Cell Biology, and Microbiology and Immunology, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA.
Nature Reviews. Immunology
|February 7, 2015
Summary
Humoral immunity relies on germinal centre (GC) reactions to create high-affinity memory B cells. Recent research details GC formation, maintenance, and cell dynamics crucial for antibody generation and immune response.
Area of Science:
- Immunology
- Cell Biology
Background:
- Humoral immunity is critical for adaptive immune responses.
- The germinal centre (GC) reaction is essential for generating high-affinity antibodies.
- Understanding GC dynamics is key to effective B cell maturation.
Purpose of the Study:
- To review recent advances in understanding germinal centre (GC) reactions.
- To highlight the role of cell dynamics in GC formation and maintenance.
- To discuss the implications of these findings for humoral immunity.
Main Methods:
- This review synthesizes findings from recent immunological studies.
- It focuses on research investigating cellular movements within GCs.
- The review integrates data on B cell selection and antibody mutation.
Main Results:
- Recent studies have identified key factors influencing GC formation and maintenance.
- Dynamic cell movements within and between GCs are crucial for GC progression.
- High-affinity antibody mutants are selected through these intricate processes.
Conclusions:
- Recent discoveries have significantly advanced our understanding of the GC reaction.
- Cellular dynamics play a pivotal role in the generation of memory B cells and plasma cells.
- These insights are vital for understanding and enhancing humoral immune responses.
Related Concept Videos
01:24B Cell Activation and Differentiation
18.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
18.7K
01:23Cells of the Adaptive Immune Response
10.3K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
10.3K
01:16Primary Lymphoid Organs
17.0K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
17.0K
01:22T Cell Activation and Clonal Selection
17.9K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
17.9K
01:28Diversity of Antigen Receptors
2.2K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
2.2K
01:36Humoral Immune Responses
88.1K
Overview
88.1K