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Risk factors of recurrence among 471 Chinese patients with Budd-Chiari syndrome

Xiuyin Gao1, Er Gui2, Zhaojun Lu1

  • 1School of Public Health, Xuzhou Medical College, Xuzhou, Jiangsu 221004, China.

Clinics and Research in Hepatology and Gastroenterology
|February 7, 2015
PubMed

Insights

The 5-year recurrence rate for Budd-Chiari syndrome (BCS) in Chinese patients is 42%. Younger age, specific types, elevated LDH, and advanced Child-Pugh class predict recurrence.

Area of Science:

  • Vascular Medicine
  • Hepatology
  • Epidemiology

Background:

  • Budd-Chiari syndrome (BCS) is a rare vascular disease with limited prognostic literature.
  • Understanding recurrence patterns and risk factors is crucial for managing BCS, particularly in specific populations like Chinese patients.

Purpose of the Study:

  • To determine the cumulative recurrence rates of BCS in Chinese patients.
  • To identify independent risk factors associated with BCS recurrence.

Main Methods:

  • A cohort of 471 BCS patients diagnosed between 2008-2012 was studied.
  • Kaplan-Meier curves assessed recurrence rates; Cox regression identified risk factors.
  • Follow-up was conducted via phone calls or correspondence.

Main Results:

  • The 5-year cumulative recurrence rate for BCS was 42%.
  • Identified risk factors for recurrence included: age ≤ 30 years, hepatic vein or combined type BCS, elevated lactate dehydrogenase (LDH), and Child-Pugh class B/C.
  • These factors were identified using univariable and multivariable Cox regression models.

Conclusions:

  • The high 5-year recurrence rate of 42% underscores the aggressive nature of BCS in this cohort.
  • Younger age, specific BCS types, elevated LDH, and advanced liver dysfunction (Child-Pugh B/C) are significant predictors of recurrence.
  • These findings are critical for risk stratification and personalized management strategies in BCS patients.
Abstract

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