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Optimal duration of an early intervention programme for first-episode psychosis: randomised controlled trial

Wing Chung Chang¹, Gloria Hoi Kei Chan¹, Olivia Tsz Ting Jim¹

¹Wing Chung Chang, MRCPsych, FHKCPsych, Gloria Hoi Kei Chan, MPhil, Olivia Tsz Ting Jim, BsocSc, Department of Psychiatry, University of Hong Kong; Emily Sin Kei Lau, BsocSc, Department of Psychiatry, Queen Mary Hospital, Hong Kong; Christy Lai Ming Hui, PhD, Sherry Kit Wa Chan, MRCPsych, Edwin Ho Ming Lee, MRCPsych, FHKCPsych, Department of Psychiatry, University of Hong Kong; Eric Yu Hai Chen, MD, Department of Psychiatry, University of Hong Kong and State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong.

The British Journal of Psychiatry : the Journal of Mental Science

|February 7, 2015

Abstract

Background:

Numerous early intervention services targeting young people with psychosis have been established, based on the premise that reducing treatment delay and providing intensive treatment in the initial phase of psychosis can improve long-term outcome.

Aims:

To establish the effect of extending a specialised early intervention treatment for first-episode psychosis by 1 year.

Method:

A randomised, single-blind controlled trial (NCT01202357) compared a 1-year extension of specialised early intervention with step-down care in patients who had all received a 2-year intensive early intervention programme for first-episode psychosis.

Results:

Patients receiving an additional year of specialised intervention had better outcomes in functioning, negative and depressive symptoms and treatment default rate than those managed by step-down psychiatric care.

Conclusions:

Extending the period of specialised early intervention is clinically desirable but may not be feasible in lower-income countries.

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