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Autism spectrum disorder in individuals with anorexia nervosa and in their first- and second-degree relatives: Danish
Susanne V Koch1, Janne T Larsen1, Svend E Mouridsen1
1Susanne V. Koch, MD, PhD, Mental Health Centre for Child and Adolescent Psychiatry, Copenhagen Region and Institute of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; Janne T. Larsen, MSc, National Center for Register-based Research, School of Business and Social Sciences, University of Aarhus, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPsych, Department of Biomedicine, Faculty of Health, Aarhus University, Denmark; Svend E. Mouridsen, MScPsych, Mette Bentz, MScPsych, Mental Health Centre for Child and Adolescent Psychiatry, Copenhagen Region, Denmark; Liselotte Petersen, MSc, PhD, National Center for Register-based Research, School of Business and Social Sciences, University of Aarhus, Aarhus, iPsych, Department of Biomedicine, Faculty of Health, Aarhus University, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; Cynthia Bulik, PhD, FAED, Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA, and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Preben B. Mortensen, MD, DMSci, National Center for Register-based Research, School of Business and Social Sciences, University of Aarhus, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPsych, Department of Biomedicine, Faculty of Health, Aarhus University, Denmark; Kerstin J. Plessen, MD, PhD, Mental Health Centre for Child and Adolescent Psychiatry, Copenhagen Region and Institute of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Background:
Clinical and population-based studies report increased prevalence of autism spectrum disorders (ASD) in individuals with anorexia nervosa and in their relatives. No nationwide study has yet been published on co-occurrence of these disorders.
Aims:
To investigate comorbidity of ASD in individuals with anorexia nervosa, and aggregation of ASD and anorexia nervosa in their relatives.
Method:
In Danish registers we identified all individuals born in 1981-2008, their parents, and full and half siblings, and linked them to data on hospital admissions for psychiatric disorders.
Results:
Risk of comorbidity of ASD in probands with anorexia nervosa and aggregation of ASD in families of anorexia nervosa probands were increased. However, the risk of comorbid and familial ASD did not differ significantly from comorbid and familial major depression or any psychiatric disorder in anorexia nervosa probands.
Conclusions:
We confirm aggregation of ASD in probands with anorexia nervosa and in their relatives; however, the relationship between anorexia nervosa and ASD appears to be non-specific.
