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Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts
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Orthotopic neobladder reconstruction.

Dwayne T S Chang1, Nathan Lawrentschuk2

  • 1Department of Urology, Fremantle Hospital and Health Service, Fremantle, Western Australia.

Urology Annals
|February 7, 2015
PubMed
Summary

Orthotopic neobladder reconstruction offers comparable or better quality of life and sexual function compared to ileal conduits after cystectomy. It is a viable alternative for suitable patients avoiding a stoma, but requires good organ function and patient compliance.

Keywords:
Erectile dysfunctionquality of lifeurinary bladderurinary diversionurinary incontinence

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Area of Science:

  • Urology
  • Oncology
  • Surgical Reconstruction

Background:

  • Orthotopic neobladder reconstruction is a growing alternative to ileal conduit urinary diversion after cystectomy for bladder cancer.
  • It aims to improve patient quality of life by avoiding a stoma and its associated complications.

Purpose of the Study:

  • To review the current aspects and potential advantages of orthotopic neobladder formation.
  • To compare neobladder outcomes with ileal conduits regarding quality of life and sexual function.

Main Methods:

  • A literature search of the PubMed database was conducted for articles published between January 1994 and April 2014.
  • Relevant full-text articles in English or with English translation were assessed for inclusion.

Main Results:

  • Patients with neobladders report comparable or better post-operative sexual function than those with ileal conduits.
  • Quality of life is comparable between neobladder and ileal conduit groups.
  • Potential risks include electrolyte abnormalities and nocturnal incontinence.

Conclusions:

  • Orthotopic neobladder is a suitable alternative to ileal conduit for patients who wish to avoid a stoma and are motivated for training.
  • Patient selection requires good renal and liver function and a high likelihood of compliance with neobladder training.