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Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Related Experiment Video

Updated: Apr 17, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

Hypertrophic cardiomyopathy: a review.

Brian A Houston¹, Gerin R Stevens¹

¹Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA.

Clinical Medicine Insights. Cardiology

|February 7, 2015

Summary

Hypertrophic cardiomyopathy (HCM) is a genetic heart disease affecting diverse populations globally. This review focuses on managing HCM patients, particularly those experiencing heart failure symptoms.

Area of Science:

Cardiology
Genetics
Heart Failure

Background:

Hypertrophic cardiomyopathy (HCM) is a prevalent global genetic heart condition.
It affects diverse populations across all continents, genders, and ethnicities.
HCM is primarily a monogenic disorder linked to sarcomeric gene mutations.

Purpose of the Study:

To review the current approach to managing patients with hypertrophic cardiomyopathy (HCM).
To specifically address the clinical management of HCM patients presenting with heart failure.
To highlight recent advancements in understanding and treating HCM and heart failure.

Main Methods:

Literature review of recent advancements in HCM and heart failure management.
Synthesis of current clinical guidelines and research findings.

Keywords:

LV hypertrophy heart failure hypertrophic cardiomyopathy

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Last Updated: Apr 17, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Published on: August 8, 2022

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Focus on diagnostic and therapeutic strategies for HCM with heart failure.

Main Results:

HCM presents a spectrum of clinical manifestations, from sudden cardiac death to heart failure symptoms.
Effective management requires a comprehensive understanding of HCM's genetic basis and clinical course.
Recent progress offers new insights into treating HCM, especially when heart failure is present.

Conclusions:

A multidisciplinary approach is crucial for managing HCM patients with heart failure.
Ongoing research continues to refine treatment strategies for hypertrophic cardiomyopathy.
Early diagnosis and tailored interventions improve outcomes for HCM patients, particularly those with heart failure.