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Related Experiment Video

Updated: Apr 17, 2026

Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
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Two-dimensional micro-displacement measurement for laser coagulation using optical coherence tomography.

Kazuhiro Kurokawa1, Shuichi Makita1, Young-Joo Hong1

  • 1Computational Optics Group, University of Tsukuba, Tsukuba, Japan ; Computational Optics and Ophthalmology Group, Tsukuba, Japan.

Biomedical Optics Express
|February 7, 2015
PubMed
Summary

This study introduces a new method using optical coherence tomography to measure tissue displacement during laser irradiation. This technique enhances the understanding of thermal responses in retinal tissue, improving photocoagulation reproducibility.

Keywords:
(120.6150) Speckle imaging(170.3340) Laser Doppler velocimetry(170.4470) Ophthalmology(170.4500) Optical coherence tomography(170.5755) Retina scanning

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Area of Science:

  • Ophthalmology
  • Biomedical Optics
  • Laser-Medical Applications

Background:

  • Reproducibility in photocoagulation requires quantitative monitoring of thermal changes in laser-irradiated retinal tissue.
  • Optical coherence tomography (OCT) offers non-invasive monitoring of structural changes during laser irradiation.
  • Existing OCT methods need enhancement for precise thermal response measurement.

Purpose of the Study:

  • To develop and validate a novel OCT-based method for measuring tissue displacement.
  • To quantitatively assess the thermal response of laser-irradiated retinal tissue.
  • To improve the understanding and reproducibility of photocoagulation procedures.

Main Methods:

  • Simultaneous use of Doppler phase shifts and correlation coefficients within OCT.
  • Theoretical modeling of the proposed displacement measurement technique.
  • Experimental validation using enucleated porcine eyes subjected to laser irradiation.

Main Results:

  • Demonstrated ability to measure both lateral and axial displacements in laser-irradiated retinal tissue.
  • Experimental confirmation of the theoretical approach for displacement measurement.
  • Successful observation of tissue responses to laser irradiation.

Conclusions:

  • The proposed OCT method effectively measures laser-induced tissue displacement.
  • This technique provides valuable insights into the direct thermal response of retinal tissue.
  • The method holds potential for improving photocoagulation reproducibility and safety.