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Multiple nontuberculous scrofulodermas showing dramatic response to clarithromycin
Kumar Parimalam1, G Senthil1, M Vinnarasan1
1Department of Dermatology, Thanjavur Medical College, Thanjavur, Tamil Nadu, India.
Indian Dermatology Online Journal
|February 7, 2015
Summary
Nontuberculous Mycobacterium chelonae infections can cause skin issues, especially after trauma. A case of scrofuloderma responded well to clarithromycin treatment.
Area of Science:
- Microbiology
- Dermatology
- Infectious Diseases
Background:
- Atypical mycobacteria, distinct from Mycobacterium tuberculosis, include Mycobacterium chelonae.
- Mycobacterium chelonae is a rapid-growing, non-pigment producing bacterium found in cutaneous sites.
- Infections typically arise after skin trauma (surgery, injections, minor injuries).
Observation:
- In immunocompetent individuals, M. chelonae infections often manifest as localized cellulitis or nodules.
- Immunocompromised patients may experience disseminated disease with over five lesions.
- The organism's resistance to standard antitubercular therapy can lead to chronic abscesses.
Findings:
- This report details a case of multiple scrofuloderma caused by nontuberculous Mycobacterium chelonae.
- The patient exhibited a significant and rapid positive response to clarithromycin therapy.
Implications:
- Clarithromycin shows promise as an effective treatment for Mycobacterium chelonae-induced scrofuloderma.
- Understanding atypical mycobacterial infections is crucial for effective dermatological and infectious disease management.
- This case highlights the importance of considering M. chelonae in cutaneous infections, particularly in at-risk populations.
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