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Published on: November 7, 2013
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Provesicles as novel drug delivery systems.
Zerrin S Bayindir, Nilufer Yuksel1
1Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Turkey. nyuksel@pharmacy.ankara.edu.tr.
Current Pharmaceutical Biotechnology
|February 7, 2015
Summary
Provesicular systems offer enhanced stability for vesicular drug delivery, overcoming limitations like aggregation and leakage. These dry preformulations transform into vesicles upon hydration, improving drug bioavailability and reducing side effects.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Vesicular systems (liposomes, niosomes) offer controlled release, targetability, and biocompatibility for improved drug bioavailability.
- Key challenges include low physicochemical stability (fusion, aggregation, leakage) and high manufacturing costs.
- These stability issues hinder the effective clinical application of vesicular drug delivery systems.
Purpose of the Study:
- To review advancements in vesicular systems, focusing on innovations that enhance stability.
- To introduce and detail the provesicular system approach as a solution to stability concerns.
- To provide comprehensive information on the composition, preparation, administration, and characterization of provesicular systems.
Main Methods:
- Review of existing literature on vesicular and provesicular drug delivery systems.
- Detailed explanation of the concept, advantages, and formulation strategies of provesicles.
- Discussion of proliposomes and proniosomes as specific examples of provesicular systems.
Main Results:
- Provesicular systems are dry, free-flowing preformulations that form stable vesicles upon hydration.
- They overcome the inherent stability issues of traditional vesicular systems.
- Provesicles combine the benefits of vesicles with improved storage stability and handling.
Conclusions:
- Provesicular systems represent a significant innovation in drug delivery, enhancing the therapeutic potential of vesicular formulations.
- The provesicle approach offers a promising strategy for developing more stable and effective drug delivery systems.
- Further research and industrial development in provesicular systems are encouraged for broader application.
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