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Quercetin regresses Dalton's lymphoma growth via suppression of PI3K/AKT signaling leading to upregulation of p53 and

Akhilendra Kumar Maurya1, Manjula Vinayak

  • 1a Biochemistry & Molecular Biology Laboratory, Centre of Advanced Study in Zoology , Banaras Hindu University , Varanasi , India.

Nutrition and Cancer
|February 7, 2015
PubMed

Insights

Quercetin, a dietary flavonoid, suppresses lymphoma by downregulating the PI3K-AKT1-p53 pathway and inhibiting cancer cell metabolism. This natural compound shows promise in lymphoma prevention and treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Oncogene deregulation drives cancerous growth via uncontrolled cell proliferation, apoptosis, and survival.
  • Phosphatidylinositol 3-kinase (PI3K) signaling is crucial in malignant transformation, with hyperactivation of PI3K, AKT1, and LDH-A, alongside p53 inactivation, promoting tumor cell growth.
  • Dietary flavonoids, like quercetin, are recognized for their potential to modulate cellular signaling pathways.

Purpose of the Study:

  • To investigate the regulatory role of quercetin on the PI3K/AKT pathway in Dalton's lymphoma mouse model.
  • To analyze the effects of quercetin on cell viability, glycolytic metabolism, and the expression of key proteins (PI3K, AKT1, p53) in lymphoma ascites cells.

Main Methods:

  • Analysis of cell viability and glycolytic metabolism in ascites cells.
  • Assessment of PI3K (regulatory and catalytic subunits), AKT1, and p53 expression and levels.
  • Evaluation of morphological parameters and survival rates of treated mice.

Main Results:

  • Hyperactivation of PI3K signaling, AKT1 activation, and p53 inactivation were observed in Dalton's lymphoma ascites cells.
  • Quercetin treatment modulated the PI3K-AKT1-p53 pathway, leading to lymphoma suppression.
  • Quercetin significantly downregulated glycolytic metabolism and demonstrated tumor suppressor activity, improving mouse longevity.

Conclusions:

  • Quercetin effectively modulates the PI3K-AKT1-p53 pathway, suggesting its potential as a therapeutic agent against lymphoma.
  • The downregulation of glycolytic metabolism by quercetin further contributes to its anti-lymphoma effects.
  • Quercetin holds promise for lymphoma prevention and treatment strategies by targeting key oncogenic signaling and metabolic pathways.

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