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The muscle-bone interaction in Turner syndrome
Ondrej Soucek1, Jana Matyskova1, Elmar Anliker2
1Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.
Bone
|February 10, 2015
Summary
Girls with Turner syndrome (TS) exhibit lower bone strength despite comparable muscle force to healthy peers. This indicates a potential alteration in how bone responds to mechanical loading in TS.
Area of Science:
- Endocrinology
- Orthopedics
- Pediatrics
Background:
- Turner syndrome (TS) is linked to elevated fracture risk due to diminished bone strength.
- Skeletal muscle force is a primary determinant of bone strength.
Purpose of the Study:
- To investigate the relationship between muscle force and bone strength in girls with TS.
- To compare this relationship in girls with TS versus healthy controls.
Main Methods:
- 39 girls with TS and 67 controls underwent one-legged hopping mechanography for maximum muscle force (Fmax) assessment.
- Peripheral quantitative computerized tomography measured bone strength index (BSI 4) and polar strength-strain index (SSI polar 66).
- Multiple linear regression analyzed the impact of TS on the muscle-bone unit.
Main Results:
- No significant difference in Fmax was found between groups (p=0.14).
- Girls with TS showed significantly lower bone strength (BSI 4: 18% lower, p<0.01; SSI polar 66: 7% lower, p=0.027) compared to controls, even after adjusting for Fmax.
- TS negatively impacted bone strength indices (p<0.001 for BSI 4, p<0.01 for SSI polar 66).
Conclusions:
- Girls with TS have reduced bone strength despite similar muscle force compared to healthy controls.
- This suggests an altered bone-loading sensitivity in Turner syndrome.
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