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Differences in angiotensin (1-7) between men and women
Jennifer C Sullivan1, Paula Rodriguez-Miguelez2, Margaret A Zimmerman1
1Department of Physiology, Georgia Regents University, Augusta, Georgia;
American Journal of Physiology. Heart and Circulatory Physiology
|February 10, 2015
Summary
Women have higher levels of angiotensin (1-7) [ANG-(1-7)] than men. This peptide impacts blood pressure and vascular function differently based on sex.
Area of Science:
- Cardiovascular Physiology
- Endocrinology
- Human Physiology
Background:
- Experimental models suggest sex differences in angiotensin (1-7) [ANG-(1-7)] levels.
- Human studies are needed to confirm if ANG-(1-7) concentrations differ between sexes.
Purpose of the Study:
- To compare circulating ANG-(1-7) concentrations in healthy men and women.
- To investigate the relationship between ANG-(1-7), vascular function, and blood pressure in a sex-dependent manner.
Main Methods:
- Cross-sectional study of 42 healthy volunteers (21 men, 21 women).
- Measured plasma ANG-(1-7) and ANG II concentrations.
- Assessed blood pressure and brachial artery flow-mediated dilation (FMD).
Main Results:
- Women showed significantly higher plasma ANG-(1-7) levels than men.
- ANG II levels were similar between sexes.
- No significant sex differences in FMD were observed.
- Sex-specific correlations found between ANG-(1-7), vascular function, and blood pressure.
Conclusions:
- Healthy women exhibit higher circulating ANG-(1-7) than men.
- The relationship between ANG-(1-7), vascular function, and diastolic blood pressure is sex-dependent.
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