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Updated: Apr 17, 2026
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Reversibly changing a painkiller structure: a hot topic for a cold case--ibuprofen lysine salt
Chiara Vladiskovic1, Norberto Masciocchi2
1Dipharma Francis s.r.l., Via Bissone 5, 20021 Baranzate, MI, Italy; Dipartimento di Scienza e Alta Tecnologia, Università dell'Insubria, Via Valleggio 11, 22100 Como, Italy.
Abstract:
Ibuprofen lysine salt can undergo a fully reversible, thermally induced phase transition into a different enantiotropically related polymorphic form. The structures of both the high and low temperature phases were solved using state-of-the-art X-ray powder diffraction methods, showing many similarities both in the molecular conformation and in the crystal packing. The full structural analysis and comparison of the two crystal structures allowed to understand the mechanism of the phase transition and explain its reversible nature in what appears to be a rare case of isosymmetric temperature-driven phase transformation of an organic solid.
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